argenx SE (ARGX)
POSITIVEFundamental
63
Price
$1026.88
Market Cap
$64.66B
Part 1 · What the company is worth
Overview
argenx is a Dutch-Belgian biotechnology company built around one drug family, sold under the brand Vyvgart, that blocks a protein the immune system uses to keep harmful antibodies in circulation. That mechanism treats a growing list of rare autoimmune diseases, starting with a form of myasthenia gravis, a disease that weakens muscles, and expanding into other conditions where the immune system attacks the body's own tissue.
How it makes money
Nearly all revenue comes from selling Vyvgart, in an infused or a self-injectable form, to patients through hospitals, specialty pharmacies and health systems across the United States, Europe and Japan. As a biologic drug for a rare disease, it is priced high per patient and carries very high gross margins; growth now comes mainly from approvals in new indications and new countries rather than from a broader product line.
Competitive moat
Patents and licences · Narrowargenx holds patents around its specific antibody and its manufacturing process, and being first to market with an approved drug in each new indication is itself an advantage. But it is not alone: a direct rival already sells a competing drug using the same biological mechanism, and others are in development, so the protection rests on execution and patent life rather than on a durable structural edge.
What drives demand
DefensiveDemand is driven by diagnosis and treatment of chronic autoimmune diseases, which does not track the economic cycle. It instead depends on how many new patients start treatment, how many indications get regulatory approval, and whether health systems agree to reimburse the drug at its price.
Key risks
- Dependence on a single drug franchise — Nearly all revenue comes from the Vyvgart franchise. A safety issue, a manufacturing problem, or slower-than-expected adoption in any major indication would affect most of the company's results at once.
- Competition targeting the same mechanism — A rival company already markets a competing drug that blocks the same protein, and other companies have similar drugs in development, which can pressure both prices and market share.
- Eventual biosimilar competition — Once patent and regulatory exclusivity expire, biosimilar versions of the drug can enter the market, as regulatory frameworks for biosimilars in autoimmune disease continue to develop.
The case for
Buyers argue that Vyvgart's mechanism can be extended into a long list of additional autoimmune diseases beyond myasthenia gravis, that being first to market with regulatory approval in each new indication builds a durable prescribing habit among specialists, and that revenue has grown very quickly as new markets and indications open.
The case against
Sellers fear that a company this dependent on one drug family is fragile to any single setback, that a rival already selling a drug with the same mechanism can erode pricing and share before argenx diversifies its pipeline, and that today's growth rate will be hard to sustain once the easiest new-indication approvals are behind it.
Written by the editors, published on August 18, 2026
Direct competitors
Who this company fights with for the same customers
Generated on August 23, 2026 with claude-opus-5 — shared with all users
A pure-play FcRn developer whose batoclimab and next-generation IMVT-1402 are aimed at the same autoimmune indications argenx has built its franchise on, and which argenx itself flags as a near-term competitive risk.
Through Alexion it sells Soliris and Ultomiris (ravulizumab), the complement inhibitors that were the standard specialty treatment in generalized myasthenia gravis before Vyvgart and still compete for the same prescriptions.
Its CD19-targeted B-cell therapy Uplizna (inebilizumab) is approved for generalized myasthenia gravis in the US and Europe and competes on convenience with twice-yearly dosing against Vyvgart's cycles.
Its FcRn blocker Imaavy (nipocalimab) targets the same generalized myasthenia gravis and CIDP patients that the Vyvgart franchise depends on, with a label covering both anti-AChR and anti-MuSK antibody-positive patients.
UCB fields two approved myasthenia gravis drugs against Vyvgart — the FcRn blocker Rystiggo (rozanolixizumab) and the complement inhibitor Zilbrysq (zilucoplan) — competing for the same neurologists and the same patients in the US and Europe.
Its immunoglobulin products, including HyQvia approved for CIDP, hold the treatment slot that Vyvgart Hytrulo is designed to take over in that indication.
Balance Sheet & Liquidity
Revenue
$5.23B
Trailing 12 months (through 6/30/2026)
Net Income
$1.72B
Trailing 12 months (through 6/30/2026)
Free Cash Flow
$762M
Total Equity
$335M
Total Liabilities
$47M
Current Ratio
5.12
Interest Coverage
-
Debt/EBITDA
0.03
Earnings Per Share
Revenue & Net Income
Free Cash Flow
Income Breakdown
Historical statement
Margins over time
Debt over time
How heavy the debt is
Growth grid
Growth — Revenue
Fair Value Estimation
Fair Value
$697.53
Current Price
$1026.88
Margin of Safety
-47.2%
Fair Value Range
$453.39 - $941.66
Estimation Methods
Valuation Metrics
P/E Ratio
39.69
ROE
23.6%
P/B Ratio
193.14
P/FCF
84.88
Gross Margin
59.1%
ROIC
351.9%
Profitability Radar
Value Creation (Economic Moat)
ROIC
351.9%
WACC
12.7%
ROIC − WACC
+339.2 pp
ROIC exceeds the cost of capital — the company is creating value for shareholders.
Fundamental Analysis Criteria
Passed (12)
- Price CAGR 36.52%
- ROIC 351.9%
- Gross Margin 59.1%
- Debt/Equity ratio
- Positive Free Cash Flow
- Current Ratio
- Debt/EBITDA
- ROE 22.4%
- Revenue Growth 5Y 151.5%
- Analyst Consensus 92% Buy
- Earnings Surprise avg 16.4%
- Earnings Quality (OCF/NI) 0.75
Failed (6)
- P/FCF 84.88
- P/B Ratio 193.14
- CapEx intensity
- DCF valuation (Overvalued)
- Net Margin Trend 30.4% vs 37.0%
- Piotroski F-Score 1/9
Unavailable (9)
- EPS data insufficient
- Dividend Payout NaN%
- Operating Margin NaN%
- Interest Coverage
- Return on Tangible Assets
- Low reliance on intangibles
- Price below Graham Number
- PEG Ratio (need PE > 0 and growth > 0)
- Share Dilution (missing shares data)
Piotroski F-Score
Serious financial concerns
Earnings Quality
Moderate: some gap between profits and cash
Share Dilution
Buying back shares. Shareholder friendly
Governance
Executive Team
| Name | Title | Age |
|---|---|---|
| Mr. Timothy Van Hauwermeiren EMBA, M.Sc. | Co-Founder & Non-Independent Non-Executive Chairman of the Board | 53 |
| Ms. Karen Massey | CEO & Executive Director | 46 |
| Mr. Karl Gubitz | Chief Financial Officer | 55 |
| Dr. Peter Ulrichts | Chief Scientific Officer | 45 |
| Ms. Malini Moorthy | General Counsel & Corporate Secretary | 55 |
| Mr. Arjen Lemmen M.Sc. | VP of Corporate Development & Strategy | 40 |
| Ms. Andria Wilk | Global Head of Quality | 52 |
| Dr. Luc Truyen | Chief Medical Officer | 60 |
| Prof. Hans de Haard Ir, Ph.D. | Co-Founder & Member of Board Advisors | 65 |
| Mr. Filip Borgions | Chief Technology Innovation Officer | - |
Part 2 · The price and when to enter
This part won't tell you whether the company is worth owning: it helps you choose when to buy it, once the fundamentals have convinced you. Inside: technical analysis, potential, historical drawdowns, gamma exposure.
Latest News
Recent headlines for ARGX, sourced from Markets Gazette.
- 4d agoPOSITIVEEurope Has Its Own Biotech Star as Argenx Soars on Trial Success
Argenx SE shares surged following positive results from a Phase 3 trial for its experimental drug, empasireg, in treating a rare autoimmune disorder. The trial met its primary endpoint, demonstrating a statistically significant improvement in patient outcomes compared to placebo. This success positions empasireg for potential regulatory approval and commercialization, significantly boosting argenx's pipeline and future revenue prospects. The strong trial data is a key catalyst, reinforcing argenx's position as a leading European biotech firm and attracting investor attention to its growth potential.
- 8d agoPOSITIVEArgenx Soars on Latest Trial Success for Autoimmune Drug Vyvgart
Argenx SE experienced a significant share price increase following the announcement of successful late-stage clinical trial results for its autoimmune disease drug, Vyvgart. The positive outcome from this large-scale trial bolsters confidence in the drug's efficacy and market potential, suggesting strong future revenue streams for the company. Investors are likely to view this development favorably, as it solidifies Vyvgart's position as a blockbuster treatment and reinforces argenx's pipeline strength. This success could lead to upward price target revisions and increased institutional interest.
- 5/25/2026POSITIVEHere's How Much $1000 Invested In argenx 5 Years Ago Would Be Worth Today
An investment of $1000 in argenx SE five years ago would have yielded a substantial return, growing to approximately $3,500 today. This significant appreciation highlights the company's strong performance and growth trajectory over the past half-decade. argenx, a global immunology company, has seen its stock price surge, driven by the successful development and commercialization of its innovative therapies, particularly in the rare disease space. Investors who held the stock have benefited from the company's pipeline advancements and market penetration, underscoring its potential as a long-term growth investment.
- 3/25/2026POSITIVE$100 Invested In argenx 5 Years Ago Would Be Worth This Much Today
An investment of $100 in argenx SE five years ago would have yielded a significant return, underscoring the company's strong performance and growth trajectory in the biotechnology sector. While specific figures for the current valuation are not provided in the snippet, the headline implies substantial capital appreciation for shareholders. This suggests successful product development, effective market penetration, and positive clinical trial outcomes, all of which contribute to increased investor confidence and a rising stock price. For potential investors, argenx's historical performance indicates a robust business model and a promising future in the competitive biopharmaceutical landscape.
- 3/4/2026POSITIVEHere's How Much $100 Invested In argenx 5 Years Ago Would Be Worth Today
An investment of $100 in argenx SE five years ago would be worth approximately $380 today, representing a total return of 280% over that period. This figure highlights the stock's strong performance in the biopharmaceutical sector, driven by therapeutic innovations and product portfolio expansion. For investors, argenx's growth trajectory suggests solid management and continued potential for capital appreciation, especially considering pipeline developments and regulatory approvals.
- 2/25/2026NEUTRALInsights into argenx's Upcoming Earnings
Investors in argenx SE (ARGX) are anticipating the company's upcoming earnings report, a pivotal event that could shape the stock's future trajectory. While the announcement provides no specific details or forecasts, market attention will be keenly focused on the biopharmaceutical firm's financial performance. Key data points such as earnings figures, future projections, and updates on clinical progress for pipeline drugs will be crucial for assessing argenx's financial health and growth prospects. The lack of pre-release insights positions this event as a potential catalyst for volatility, with the stock likely to react significantly based on any positive or negative surprises in the reported results.
via Markets Gazette